PSORIASIFORM DRUG ERUPTION INDUCED BY ANTI-TUBERCULOSIS MEDICATION: A CASE REPORT

Objective: Psoriasiform drug eruptions can be induced by several drugs. Psoriasis is a chronic inflammatory disease characterized T-cell-mediated cytokine production that drives the hyperproliferation and abnormal differentiation of keratinocytes. Drugs cause new lesions when there no prior history or family psoriasis. Based on psoriatic eruption probability score, β‐blockers, synthetic anti‐malarial drugs, non‐steroidal anti‐inflammatory drugs (NSAIDs), lithium, digoxin tetracycline antibiotics are relevant in psoriasis.
 Methods: A 58-year-old male was admitted to Department Respiratory Medicine at B. P. S G. M. C, Khanpur Kalan, Sonepat as case pulmonary tuberculosis put anti-tubercular CAT-I (according RNTCP guidelines). The patient had diabetes mellitus hypertension for past six years. On third day initiation ATT, started developing psoriasiform rash. rash began improve within few days after discontinuing ATT. causality assessment done per WHO-UMC scale, which showed adverse events were likely caused due ATT.
 Results: severe reaction widespread lesions. Among all various reactions, lichenoid commonly associated with anti-tuberculosis medication needs differentiated from eruption. underlying pathomechanism drug-induced remains uncertain, although immunological interactions have been hypothesized.
 Conclusion: ATT has reported rash, its component reconsidered view safer alternatives available.